Lipid regulation of homeostatic processes including metabolism.Lipids in functional membrane domains and membrane processes.To offer examples of successful strategies for dissecting the multifaceted roles of lipids in physiology and pathology, the authors are welcome to submit original articles or reviews addressing advances in the following aspects of lipid biology: These recent studies will delineate successful strategies to characterize lipid molecules and their interacting partners to provide mechanistic insights into the role of lipids in physiological and pathophysiological states. Without the presumption of being a complete account, this article collection has the scope to provide scientists approaching lipid studies with an array of multidisciplinary exemplars on how to dissect lipid function in health and disease. Several experimental approaches have been set up to rule out lipid biological function and its relevance to human diseases and metabolic disorders. Although largely based on mass spectrometry, lipid research is far from being limited to an array of analytical techniques to elucidate lipid composition. Notably, the recent success of the field also calls for increased analytical standardization, especially in the quantification of individual lipid species.
lipidomics, is a relatively young and interdisciplinary field of study that seeks to understand the biological roles of lipids. Hence, elucidating the multifaceted roles of lipids in physiology and their various dysregulations in pathology requires firstly mapping the exact lipid composition of tissues, cells, organelles, their membranes, and how it could change in time secondly, a thorough understanding of the physical properties of lipids in biomembranes finally, the functional characterization of the partners interacting with lipids, including enzymes, transporters, and transcription factors, for bringing the keys to decipher molecular mechanisms leading the diseases. Beside the biological functions, an interdisciplinary approach could figure how lipid composition can be manipulated for novel therapies. Not surprisingly, quantitative and/or qualitative alteration of lipid composition can lead to a wide spectrum of human pathologies, ranging from cancer to metabolic, cardiovascular and neurodegenerative diseases. Their different chemical structures exert a variety of biological functions including energy production, membrane structural scaffold, sorting and regulation of membrane proteins, cellular signaling, and vesicle trafficking. The human lipidome is made of thousands of lipid molecules.
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